Publication Beamlines Strategic Pillar
Lacbay, Cyrus M.; Waller, Daniel D.; Park, Jaeok; Gómez Palou, Mònica; Vincent, Félix et al. (2018). Unraveling the Prenylation–Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors. Journal of Medicinal Chemistry 61(15) , 6904-6917. 10.1021/acs.jmedchem.8b00886. [PDB: 6c56, 6c57] CMCF-ID Health
Loewen, Peter C.; Switala, Jacek; Wells, James P.; Huang, Fang; Zara, Anthony T. et al. (2018). Structure and function of a lignostilbene-α,β-dioxygenase orthologue from Pseudomonas brassicacearum. BMC Biochemistry 19(1) . 10.1186/s12858-018-0098-4. [PDB: 5v2d] CMCF-BM Health
Jha, Vikash; Ling, Hong (2018). Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender. Journal of Molecular Biology 430(11) , 1577-1589. 10.1016/j.jmb.2018.04.023. [PDB: 6brx, 6bs1] CMCF-ID Health
Blackler, Ryan J.; López-Guzmán, Arturo; Hager, Fiona F.; Janesch, Bettina; Martinz, Gudrun et al. (2018). Structural basis of cell wall anchoring by SLH domains in Paenibacillus alvei. Nature Communications 9(1) . 10.1038/s41467-018-05471-3. [PDB: 6cwc, 6cwh, 6cwi, 6cwl, 6cwm, 6cwn, 6cwr] CMCF-ID Health
Hamaguchi, Hisao; Amano, Yasushi; Moritomo, Ayako; Shirakami, Shohei; Nakajima, Yutaka et al. (2018). Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor. Bioorganic and Medicinal Chemistry 26(18) , 4971-4983. 10.1016/j.bmc.2018.08.005. [PDB: 6aak] CMCF-ID Health
Tarade, Daniel; Robinson, Claire M.; Lee, Jeffrey E.; Ohh, Michael (2018). HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease. Nature Communications 9(1) . 10.1038/s41467-018-05554-1. [PDB: 6bvb] CMCF-ID Health
Ozer, Hatice Gulcin; El-Gamal, Dalia; Powell, Ben; Hing, Zachary A.; Blachly, James S. et al. (2018). BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discovery 8(4) , 458-477. 10.1158/2159-8290.cd-17-0902. [PDB: 5wma] CMCF-ID Health
Guo, Shuaiqi; Langelaan, David N.; Phippen, Sean W.; Smith, Steven P.; Voets, Ilja K. et al. (2018). Conserved structural features anchor biofilm‐associated RTX –adhesins to the outer membrane of bacteria. FEBS Journal 285(10) , 1812-1826. 10.1111/febs.14441. CMCF-ID Health
Labandera, Anne-Marie; Uhrig, R. Glen; Colville, Keaton; Moorhead, Greg B.; Ng, Kenneth K. S. et al. (2018). Structural basis for the preference of the Arabidopsis thaliana phosphatase RLPH2 for tyrosine-phosphorylated substrates. Science Signaling 11(524) , eaan8804. 10.1126/scisignal.aan8804. [PDB: 5vjv, 5vjw] CMCF-BM Health
Hettle, Andrew G.; Vickers, Chelsea; Robb, Craig S.; Liu, Feng; Withers, Stephen G. et al. (2018). The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme. Structure 26(5) , 747-758.e4. 10.1016/j.str.2018.03.012. [PDB: 6b0k] CMCF-ID Health
Ulaganathan, ThirumalaiSelvi; Banin, Ehud; Helbert, William; Cygler, Miroslaw (2018). Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans. Journal of Biological Chemistry 293(29) , 11564-11573. 10.1074/jbc.ra118.003659. [PDB: 6d2c, 6d3u] CMCF-BM, CMCF-ID Health
Trofimova, Daria; Paydar, Mohammadjavad; Zara, Anthony; Talje, Lama; Kwok, Benjamin H. et al. (2018). Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate. Nature Communications 9(1) . 10.1038/s41467-018-05025-7. [PDB: 6bbn] CMCF-ID Health
Chen, Yun; Murillo-Solano, Claribel; Kirkpatrick, Melanie G.; Antoshchenko, Tetyana; Park, Hee-Won et al. (2018). Repurposing drugs to target the malaria parasite unfolding protein response. Scientific Reports 8(1) . 10.1038/s41598-018-28608-2. [PDB: 5umb] CMCF-ID Health
Gebai, Ahmad; Gorelik, Alexei; Nagar, Bhushan (2018). Crystal structure of saposin D in an open conformation. Journal of Structural Biology 204(2) , 145-150. 10.1016/j.jsb.2018.07.011. [PDB: 5u85] CMCF-ID Health
Jones, Michael D.; Chan, Anson C. K.; Nomellini, John F.; Murphy, Michael E. P.; Smit, John et al. (2016). Surface-layer protein fromCaulobacter crescentus: expression, purification and X-ray crystallographic analysis. Acta Crystallographica Section F:Structural Biology Communications 72(9) , 677-680. 10.1107/s2053230x16011638. CMCF-ID Health