Publication Beamlines Strategic Pillar
Huhn, Annissa J.; Gardberg, Anna S.; Poy, Florence; Brucelle, Francois; Vivat, Valerie et al. (2020). Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. ChemMedChem 15(11) . 10.1002/cmdc.202000007. [PDB: 6v8n] CMCF-ID Health
Mitcheltree, Matthew J.; Li, Derun; Achab, Abdelghani; Beard, Adam; Chakravarthy, Kalyan et al. (2020). Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy. ACS Medicinal Chemistry Letters 11(4) , 582-588. 10.1021/acsmedchemlett.0c00058. [PDB: 6v7c] CMCF-ID Health
Khan, Nimra; Pelletier, Dylan; Veyron, Simon; Croteau, Nathalie; Ichikawa, Muneyoshi et al. (2019). Crystal structure of human PACRG in complex with MEIG1. FEMS Microbiology Ecology . 10.1101/783373. [PDB: 6ndu, 6ucc] CMCF-ID Health
Jones, Carys S.; Sychantha, David; Howell, P. Lynne; Clarke, Anthony J. (2020). Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus. Journal of Biological Chemistry 295(24) , jbc.RA120.013108. 10.1074/jbc.ra120.013108. [PDB: 6wn9] CMCF-BM Health
Holt, Christian; Hamborg, Louise; Lau, Kelvin; Brohus, Malene; Sørensen, Anders Bundgaard et al. (2020). The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. Journal of Biological Chemistry 295(22) , jbc.RA120.013430. 10.1074/jbc.ra120.013430. [PDB: 6y4p] CMCF-BM Health
Gobeil, Sophie M. C.; Ebert, Maximillian C. C. J. C.; Park, Jaeok; Gagné, Donald; Doucet, Nicolas et al. (2019). The Structural Dynamics of Engineered β-Lactamases Vary Broadly on Three Timescales yet Sustain Native Function. Scientific Reports 9(1) . 10.1038/s41598-019-42866-8. [PDB: 4r4s] CMCF-ID Health
Manenda, Mahder S.; Picard, Marie-Ève; Zhang, Liping; Cyr, Normand; Zhu, Xiaojun et al. (2020). Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations. Journal of Biological Chemistry 295(14) , jbc.RA119.011212. 10.1074/jbc.ra119.011212. [PDB: 6u0p, 6u0s] CMCF-ID Health
Hersch, Steven J.; Watanabe, Nobuhiko; Stietz, Maria Silvina; Manera, Kevin; Kamal, Fatima et al. (2020). Envelope stress responses defend against type six secretion system attacks independently of immunity proteins. Nature Microbiology 5(5) . 10.1038/s41564-020-0672-6. [PDB: 6v98] CMCF-BM Health
Mendoza, Matthew N.; Jian, Mike; King, Moeko T.; Brooks, Cory L. (2020). Role of a noncanonical disulfide bond in the stability, affinity, and flexibility of a VHH specific for the Listeria virulence factor InlB. Protein Science 29(4) , 1004-1017. 10.1002/pro.3831. [PDB: 6u12, 6u14] CMCF-ID Health
Li, Franco K.K.; Rosell, Federico I.; Gale, Robert T.; Simorre, Jean-Pierre; Brown, Eric D. et al. (2020). Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase. Journal of Biological Chemistry 295(9) , 2629-2639. 10.1074/jbc.ra119.011469. [PDB: 6uex, 6uf3, 6uf5, 6uf6] CMCF-ID Health
Alonzo, Diego A.; Chiche-Lapierre, Clarisse; Tarry, Michael J.; Wang, Jimin; Schmeing, T. Martin et al. (2020). Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Nature Chemical Biology 16(5) . 10.1038/s41589-020-0481-5. [PDB: 6ulz] CMCF-ID Health
Majdi Yazdi, Mohadeseh; Saran, Sagar; Mrozowich, Tyler; Lehnert, Cheyanne; Patel, Trushar R. et al. (2020). Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase. Journal of Structural Biology 209(1) . 10.1016/j.jsb.2019.107409. [PDB: 6tzu, 6u01] CMCF-BM, CMCF-ID Health
Herrmann, Jonathan; Li, Po-Nan; Jabbarpour, Fatemeh; Chan, Anson C. K.; Rajkovic, Ivan et al. (2019). A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly. Proceedings of the National Academy of Sciences of the United States of America 117(1) , 388-394. 10.1073/pnas.1909798116. [PDB: 6p5t] CMCF-ID Health
Mascle, Xavier H.; Gagnon, Christina; Wahba, Haytham M.; Lussier-Price, Mathieu; Cappadocia, Laurent et al. (2020). Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner. Structure 28(2) . 10.1016/j.str.2019.11.019. [PDB: 6uyo, 6uyp, 6uyq, 6uyr, 6uyu, 6uyz] CMCF-ID Health
Gassaway, Brandon M.; Cardone, Rebecca L.; Padyana, Anil K.; Petersen, Max C.; Judd, Evan T. et al. (2019). Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production. Cell Reports 29(11) , 3394-3404.e9. 10.1016/j.celrep.2019.11.009. [PDB: 6ech] CMCF-ID Health