Publication Beamlines Strategic Pillar
Mellouk, Abdelkader; Ngo, Kenny; Kezzo, Ahmad A.; Martini, Cyrielle; França, Tanos C. C. et al. (2026). Mechanism of trans-envelope bacterial polysaccharide secretion in Class-3 outer-membrane polysaccharide export (OPX) protein systems. Nature Communications . 10.1038/s41467-025-67321-3. CMCF-BM Health
Di Lello, Paola; Wells, Marta M.; Davis, Ben; Daniels, Zoe; Garner, Thomas P. et al. (2026). Targeting PTPN22 at Nonorthosteric Binding Sites─A Fragment Approach. ACS Omega . 10.1021/acsomega.5c11028. CMCF-BM Health
Thavalingam, Annoj; Cheng, Zhi; Garcia, Bianca; Huang, Xue; Shah, Megha et al. (2019). Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Communications 10(1) . 10.1038/s41467-019-10577-3. CMCF-BM Health
Lee, Eunjeong; Redzic, Jasmina S.; Gordon, Blaine; Saviola, Anthony J.; Tran, Norman et al. (2025). Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes. Protein Science 35(1) . 10.1002/pro.70411. CMCF-BM Health
Jaime-Garza, Maru; Waight, Andrew; Hudlikar, Manish; Eddins, Michael J.; Rasti, Elnaz S. et al. (2025). Structural Characterization of Linker Shielding in ADC Site-Specific Conjugates. Pharmaceutics 17(12) , 1568. 10.3390/pharmaceutics17121568. [PDB: 9z0f] CMCF-BM Health
Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne et al. (2024). Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood 144(11) , 1206-1220. 10.1182/blood.2023022480. [PDB: 9z4x] CMCF-ID Health
Kimani, Serah W.; Noureldin, Mahmoud; Wilson, Brian; Hoffer, Laurent; Green, Stuart R. et al. (2025). OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications Biology 8(1) . 10.1038/s42003-025-08491-0. [PDB: 9yv4] CMCF-ID Health
Wang, Mingyu; Du, Grace; Yongo‐Luwawa, Charity; Lu, Angelina; Kinrade, Brett et al. (2025). Peptide‐based ligand antagonists block a Vibrio cholerae adhesin. FEBS Letters . 10.1002/1873-3468.70231. [PDB: 9y9w, 9ybq] CMCF-ID Health
Luo, Chuanyun; Paetzel, Mark (2025). Crystal structure of Escherichia coli type I signal peptidase P84A in complex with lipopeptide antibiotic arylomycin A2. Journal of Structural Biology 217(4) , 108260. 10.1016/j.jsb.2025.108260. [PDB: 9nlo] CMCF-ID Health
Forrester, Taylor J. B.; Lin, Sicheng; Lowary, Todd L.; Kimber, Matthew S. (2025). WrtF from Rhizobium tropici CIAT 899 is a GT-A fold fucosyltransferase that binds its donor nonproductively. Proceedings of the National Academy of Sciences of the United States of America 122(44) . 10.1073/pnas.2512460122. [PDB: 9omh, 9omi] CMCF-BM, CMCF-ID Agriculture
Ereño-Orbea, June; Pang, Lijuan; Sicard, Taylor; Nycholat, Corwin; Cui, Hong et al. (2025). Molecular Insights into the Engagement of High-Affinity Sialylated Ligands to Human CD22. JACS Au . 10.1021/jacsau.5c01013. [PDB: 9ro7, 9rob] CMCF-BM, CMCF-ID Health
Bekkering, Ezra T.; Yoo, Randy; Hailemariam, Sophia; Heide, Fabian; Ivanochko, Danton et al. (2025). Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity. Immunity . 10.1016/j.immuni.2025.09.014. [PDB: 9n7k] CMCF-ID Health
Uguen, Mélanie; Shell, Devan J.; Silva, Madhushika; Deng, Yu; Li, Fengling et al. (2025). Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells. Nature Communications 16(1) . 10.1038/s41467-025-57005-3. [PDB: 9cuw, 9cux] CMCF-BM Health
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Health
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Health