Publication Beamlines Strategic Pillar
Li, Zhijie; Fischer, Michael; Satkunarajah, Malathy; Zhou, Dongxia; Withers, Stephen G. et al. (2017). Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1). Nature Communications 8(1) . 10.1038/s41467-017-00255-7. [PDB: 5l0r, 5l0s, 5l0t] CMCF-ID Health
Copp, William; Denisov, Alexey Y.; Xie, Jingwei; Noronha, Anne M.; Liczner, Christopher et al. (2017). Influence of nucleotide modifications at the C2’ position on the Hoogsteen base-paired parallel-stranded duplex of poly(A) RNA. Nucleic Acids Research 45(17) , 10321-10331. 10.1093/nar/gkx713. [PDB: 5vxq] CMCF-ID Health
Hu, Jinhong; Komakula, Aruna; Fraser, Marie E. (2017). Binding of hydroxycitrate to human ATP-citrate lyase. Acta Crystallographica Section D: Structural Biology 73(8) , 660-671. 10.1107/s2059798317009871. [PDB: 5tde, 5tdf, 5tdm, 5tdz, 5te1, 5teq, 5tes, 5tet] CMCF-BM, CMCF-ID Health
Eble, Johannes A.; McDougall, Matthew; Orriss, George L.; Niland, Stephan; Johanningmeier, Benjamin et al. (2017). Dramatic and concerted conformational changes enable rhodocetin to block α2β1 integrin selectively. PLoS Biology 15(7) , e2001492. 10.1371/journal.pbio.2001492. [PDB: 5thp] CMCF, CMCF-ID Health
Wilsbacher, Julie L.; Cheng, Min; Cheng, Dong; Trammell, Samuel A.J.; Shi, Yan et al. (2017). Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Molecular Cancer Therapeutics 16(7) , 1236-1245. 10.1158/1535-7163.mct-16-0819. [PDB: 5u2m] CMCF-ID Health
Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana et al. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84] CMCF-ID Health
Lizak, Christian; Worrall, Liam J.; Baumann, Lars; Pfleiderer, Moritz M.; Volkers, Gesa et al. (2017). X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid. Scientific Reports 7(1) . 10.1038/s41598-017-05627-z. [PDB: 5wc6, 5wcn, 5wd7] CMCF-BM, CMCF-ID Health
Zhao, Jianhua; Beyrakhova, Ksenia; Liu, Yao; Alvarez, Claudia P.; Bueler, Stephanie A. et al. (2017). Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein. PLoS Pathogens 13(6) , e1006394. 10.1371/journal.ppat.1006394. [PDB: 5uf5, 5ufk] CMCF-BM, CMCF-ID Health
Radka, Christopher D.; DeLucas, Lawrence J.; Wilson, Landon S.; Lawrenz, Matthew B.; Perry, Robert D. et al. (2017). Crystal structure ofYersinia pestisvirulence factor YfeA reveals two polyspecific metal-binding sites. Acta Crystallographica Section D: Structural Biology 73(7) , 557-572. 10.1107/s2059798317006349. [PDB: 5uy0, 5uy4, 5uy5, 5uya, 5uyb, 5uyc, 5uyd, 5uye, 5uyf] CMCF-ID Health
Noguchi, Masato; Nomura, Akihiro; Murase, Ken; Doi, Satoki; Yamaguchi, Keishi et al. (2017). Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment. Genes to Cells 22(6) , 535-551. 10.1111/gtc.12494. [PDB: 5x8q] CMCF-ID Health
Zhang, Wei; Bailey-Elkin, Ben A.; Knaap, Robert C. M.; Khare, Baldeep; Dalebout, Tim J. et al. (2017). Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathogens 13(5) , e1006372. 10.1371/journal.ppat.1006372. [PDB: 5v5g, 5v5h, 5v6a] CMCF-BM, CMCF-ID Health
Hynes, John; Wu, Hong; Kempson, James; Duan, James J.-W.; Lu, Zhonghui et al. (2017). Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors. Bioorganic and Medicinal Chemistry Letters 27(14) , 3101-3106. 10.1016/j.bmcl.2017.05.043. [PDB: 5vo6] CMCF-ID Health
Li, Zhijie; Han, Kristina; Pak, John E; Satkunarajah, Malathy; Zhou, Dongxia et al. (2017). Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1. Nature Chemical Biology 13(7) . 10.1038/nchembio.2381. [PDB: 5kxh, 5kxq, 5ky0, 5ky2, 5ky3, 5ky4, 5ky5, 5ky7, 5ky8, 5ky9] CMCF-ID Health
Huang, Xin; Chen, Hao; Shaffer, Paul L. (2017). Crystal Structures of Human GlyRα3 Bound to Ivermectin. Structure 25(6) , 945-950. 10.1016/j.str.2017.04.007. [PDB: 5vdi] CMCF-ID Health
McCallum, Matthew; Tammam, Stephanie; Khan, Ahmad; Burrows, Lori L.; Howell, P. Lynne et al. (2017). The molecular mechanism of the type IVa pilus motors. Nature Communications 8(1) . 10.1038/ncomms15091. [PDB: 5tsg, 5tsh] CMCF-ID Health