Publication Beamlines Strategic Pillar
Cottrell, Kevin M.; Briggs, Kimberly J.; Whittington, Douglas A.; Jahic, Haris; Ali, Janid A. et al. (2024). Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers. Journal of Medicinal Chemistry 67(8) , 6064-6080. 10.1021/acs.jmedchem.4c00133. [PDB: 8veu] CMCF-ID Health
Crawford, Terry D.; Audia, James E.; Bellon, Steve; Burdick, Daniel J.; Bommi-Reddy, Archana et al. (2017). GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Medicinal Chemistry Letters 8(7) , 737-741. 10.1021/acsmedchemlett.7b00132. [PDB: 5v84] CMCF-ID Health
Crawford, Terry D.; Romero, F. Anthony; Lai, Kwong Wah; Tsui, Vickie; Taylor, Alexander M. et al. (2016). Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. Journal of Medicinal Chemistry 59(23) , 10549-10563. 10.1021/acs.jmedchem.6b01022. [PDB: 5ktw] CMCF-ID Health
Crawford, Terry D.; Tsui, Vickie; Flynn, E. Megan; Wang, Shumei; Taylor, Alexander M. et al. (2016). Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains. Journal of Medicinal Chemistry 59(11) , 5391-5402. 10.1021/acs.jmedchem.6b00264. [PDB: 5i29] CMCF-ID Health
Cregg, James; Edwards, Anne V.; Chang, Stephanie; Lee, Bianca J.; Knox, John E. et al. (2025). Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02314. [PDB: 9bg0, 9bg2, 9bg3, 9bg4, 9bg5, 9bg6, 9bg8, 9bga, 9bgb, 9bgc, 9bgd] CMCF-ID Health
Cregg, James; Pota, Kristof; Tomlinson, Aidan C. A.; Yano, Jason; Marquez, Abby et al. (2025). Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c02313. [PDB: 9bfv, 9bfw] CMCF-ID Health
Critton, D.A. (2024). Crystal structure of monkey TLR7 ectodomain with compound 14. Protein Data Bank: 8s9h. CMCF-ID Health
Crowe, Adam M.; Workman, Sean D.; Watanabe, Nobuhiko; Worrall, Liam J.; Strynadka, Natalie C. J. et al. (2018). IpdAB, a virulence factor in Mycobacterium tuberculosis , is a cholesterol ring-cleaving hydrolase. Proceedings of the National Academy of Sciences of the United States of America 115(15) , E3378-E3387. 10.1073/pnas.1717015115. [PDB: 6co6, 6co9, 6coj, 6con] CMCF-BM Health
Crowe, A.M.; Workman, S.D.; Watanabe, N.; Worrall, L.J.; Strynadka, N.C.J. et al. (2018). Crystal structure of Mycobacterium tuberculosis IpdAB. Protein Data Bank: 6con. CMCF-BM Health
Crowe, A.M.; Workman, S.D.; Watanabe, N.; Worrall, L.J.; Strynadka, N.C.J. et al. (2018). Crystal structure of Rhodococcus jostii RHA1 IpdAB E105A COCHEA-COA complex. Protein Data Bank: 6coj. CMCF-BM Health
Crowe, A.M.; Workman, S.D.; Watanabe, N.; Worrall, L.J.; Strynadka, N.C.J. et al. (2018). Crystal structure of Rhodococcus jostii RHA1 IpdAB COCHEA-COA complex. Protein Data Bank: 6co9. CMCF-BM Health
Crowe, A.M.; Workman, S.D.; Watanabe, N.; Worrall, L.J.; Strynadka, N.C.J. et al. (2018). Crystal structure of Rhodococcus jostii RHA1 IpdAB. Protein Data Bank: 6co6. CMCF-BM Health
Culp, E.J.; Sychantha, D.; Hobson, C.; Pawlowski, A.J.; Prehna, G. et al. (2022). Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene. Protein Data Bank: 7mk5. CMCF-BM Health
Cummer, Rebecca; Grosjean, Félix; Bolteau, Raphaël; Vasegh, Seyed Ehsan; Veyron, Simon et al. (2024). Structure-activity relationship of inositol thiophosphate analogs as allosteric activators of Clostridioides difficile toxin B. Applied Spectroscopy Reviews . 10.26434/chemrxiv-2024-2cf6g-v2. [PDB: 9bja] CMCF-ID Health
Curtin, Michael L.; Pliushchev, Marina A.; Li, Huan-Qiu; Torrent, Maricel; Dietrich, Justin D. et al. (2017). SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorganic and Medicinal Chemistry Letters 27(7) , 1576-1583. 10.1016/j.bmcl.2017.02.030. [PDB: 5u69, 5u6d] CMCF-ID Health