Publication Beamlines Strategic Pillar
Szabla, Robert; Li, Mingyi; Warner, Victoria; Song, Yifeng; Junop, Murray et al. (2024). DdrC, a unique DNA repair factor from D. radiodurans, senses and stabilizes DNA breaks through a novel lesion-recognition mechanism. Nucleic Acids Research 52(15) , 9282-9302. 10.1093/nar/gkae635. CMCF-BM, CMCF-ID Health
Dolgova, Natalia; Uhlemann, Eva-Maria E; Boniecki, Michal T; Vizeacoumar, Frederick S; Ara, Anjuman et al. (2024). MEMO1 binds iron and modulates iron homeostasis in cancer cells. eLife 13. 10.7554/elife.86354. CMCF-BM, CMCF-ID Health
Naineni, Sai Kiran; Bhatt, Garvit; Jiramongkolsiri, Ekkanat; Robert, Francis; Cencic, Regina et al. (2024). Protein–RNA interactions mediated by silvestrol—insight into a unique molecular clamp. Nucleic Acids Research 52(20) , 12701-12711. 10.1093/nar/gkae824. CMCF-ID Health
Kozlov, Guennadi; Jiang, Jianning; Rutherford, Tyler; Noronha, Anne M.; Wilds, Christopher J. et al. (2024). Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1. RNA Biology 21(1) , 764-773. 10.1080/15476286.2024.2379121. CMCF-ID Health
Chen, Pu; Van Oers, Tayla J.; Arutyunova, Elena; Fischer, Conrad; Wang, Chaoxiang et al. (2024). A Structural Comparison of Oral SARS-CoV-2 Drug Candidate Ibuzatrelvir Complexed with the Main Protease (Mpro) of SARS-CoV-2 and MERS-CoV. JACS Au 4(8) , 3217-3227. 10.1021/jacsau.4c00508. CMCF-ID Health
Guo, Shuaiqi; Zahiri, Hossein; Stevens, Corey; Spaanderman, Daniel C.; Milroy, Lech-Gustav et al. (2021). Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a peptide-binding domain. Cell Reports 37(7) , 110002. 10.1016/j.celrep.2021.110002. [PDB: 6x5v, 6x5w] CMCF-ID Agriculture
Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne et al. (2024). Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias. Blood 144(11) , 1206-1220. 10.1182/blood.2023022480. [PDB: 9z4x] CMCF-ID Health
Legare, Scott; Heide, Fabian; Gabir, Haben; Rafiei, Faride; Meier, Markus et al. (2024). Identifying the molecular basis of Laminin N-terminal domain Ca2+ binding using a hybrid approach. Biophysical Journal 123(16) , 2422-2430. 10.1016/j.bpj.2024.06.005. CMCF-ID Health
Heide, Fabian; Stetefeld, Jörg (2022). A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology. Nanomaterials 12(22) , 4080. 10.3390/nano12224080. CMCF, CMCF-ID Agriculture
Heide, Fabian; McDougall, Matthew; Harder-Viddal, Candice; Roshko, Roy; Davidson, David et al. (2021). Boron rich nanotube drug carrier system is suited for boron neutron capture therapy. Scientific Reports 11(1) . 10.1038/s41598-021-95044-0. CMCF, CMCF-ID Health
Prasad, Lata; Leduc, Yvonne; Hayakawa, Koto; Delbaere, Louis T. J. (2004). The structure of a universally employed enzyme: V8 protease fromStaphylococcus aureus. Acta Crystallographica Section D Biological Crystallography 60(2) , 256-259. 10.1107/s090744490302599x. [PDB: 2o8l] CMCF-ID Health
Asar, Radwa; Dhindwal, Poonam; Ruzzini, Antonio (2024). Structural and functional analysis of a bile salt hydrolase from the bison microbiome. Journal of Biological Chemistry 300(10) , 107769. 10.1016/j.jbc.2024.107769. [PDB: 8vrx] CMCF-ID Health
Cyr, Patrick; Fader, Lee D.; Burch, Jason D.; Pike, Kelly A.; Sietsema, Daniel V. et al. (2024). Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization. ACS Medicinal Chemistry Letters 15(12) , 2201-2209. 10.1021/acsmedchemlett.4c00471. [PDB: 9mdc] CMCF-ID Health
Vu, Binh T.; Dominique, Romyr; Fahr, Bruce J.; Li, Hongju H.; Fry, David C. et al. (2024). Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development. ACS Medicinal Chemistry Letters . 10.1021/acsmedchemlett.4c00379. [PDB: 9br4] CMCF-ID Health
Poullennec, Karine G.; Jnoff, Eric; Abendroth, Jan; Bhuma, Naresh; Calmiano, Mark et al. (2024). Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. Journal of Medicinal Chemistry 67(23) , 20879-20910. 10.1021/acs.jmedchem.4c01237. [PDB: 8uoj] CMCF-ID Health