Publication Beamlines Strategic Pillar
Arnal, Gregory; Stogios, Peter J.; Asohan, Jathavan; Skarina, Tatiana; Savchenko, Alexei et al. (2018). Structural enzymology reveals the molecular basis of substrate regiospecificity and processivity of an exemplar bacterial glycoside hydrolase family 74 endo-xyloglucanase. Biochemical Journal 475(24) , 3963-3978. 10.1042/bcj20180763. [PDB: 6mgl] CMCF-ID Health
Bagal, Sharan K.; Andrews, Mark; Bechle, Bruce M.; Bian, Jianwei; Bilsland, James et al. (2018). Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. Journal of Medicinal Chemistry 61(15) , 6779-6800. 10.1021/acs.jmedchem.8b00633. [PDB: 6dkb] CMCF-ID Health
Bagal, Sharan K.; Omoto, Kiyoyuki; Blakemore, David C.; Bungay, Peter J.; Bilsland, James G. et al. (2018). Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. Journal of Medicinal Chemistry 62(1) , 247-265. 10.1021/acs.jmedchem.8b00280. [PDB: 6d20] CMCF-ID Health
Baral, Pravas Kumar; Swayampakula, Mridula; Aguzzi, Adriano; James, Michael N. G. (2018). Structural characterization of POM 6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS Journal 285(9) , 1701-1714. 10.1111/febs.14438. [PDB: 6aq7] CMCF-BM Health
Beyrakhova, Ksenia; Li, Lei; Xu, Caishuang; Gagarinova, Alla; Cygler, Miroslaw et al. (2018). Legionella pneumophila effector Lem4 is a membrane-associated protein tyrosine phosphatase. Journal of Biological Chemistry 293(34) , 13044-13058. 10.1074/jbc.ra118.003845. [PDB: 6cdw, 6cgj] CMCF-ID Health
Blackler, Ryan J.; López-Guzmán, Arturo; Hager, Fiona F.; Janesch, Bettina; Martinz, Gudrun et al. (2018). Structural basis of cell wall anchoring by SLH domains in Paenibacillus alvei. Nature Communications 9(1) . 10.1038/s41467-018-05471-3. [PDB: 6cwc, 6cwh, 6cwi, 6cwl, 6cwm, 6cwn, 6cwr] CMCF-ID Health
Blank, Matthew L.; Parker, Michelle L.; Ramaswamy, Raghavendran; Powell, Cameron J.; English, Elizabeth D. et al. (2018). A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Molecular Microbiology 108(5) , 519-535. 10.1111/mmi.13947. [PDB: 6bxr, 6bxs] CMCF-BM, CMCF-ID Health
Bonday, Zahid Q.; Cortez, Guillermo S.; Grogan, Michael J.; Antonysamy, Stephen; Weichert, Ken et al. (2018). LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Medicinal Chemistry Letters 9(7) , 612-617. 10.1021/acsmedchemlett.8b00014. [PDB: 6ckc] CMCF-ID Health
Bonnick, Patrick; Blanc, Lauren; Vajargah, Shahrzad Hosseini; Lee, Chang-Wook; Sun, Xiaoqi et al. (2018). Insights into Mg2+ Intercalation in a Zero-Strain Material: Thiospinel MgxZr2S4. Chemistry of Materials 30(14) , 4683-4693. 10.1021/acs.chemmater.8b01345. CMCF-BM Materials
Bulmer, David; Kar, Gourango; Hamilton, Jordan; Siciliano, Steven; Peak, Derek et al. (2018). Extent and Mechanism of Interaction between Phosphate and Citrate in a Calcareous Soil. Soil Science Society of America Journal 82(2) , 315-322. 10.2136/sssaj2017.08.0289. CMCF-BM, SXRMB Environment
Caldwell, Shane J.; Berghuis, Albert M. (2018). Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2″)-Ia. Antimicrobial Agents and Chemotherapy 62(7) , e00202-18. 10.1128/aac.00202-18. [PDB: 6c5u, 6cav, 6cey, 6cgd, 6cgg, 6ch4] CMCF-ID Health
Chen, Yun; Murillo-Solano, Claribel; Kirkpatrick, Melanie G.; Antoshchenko, Tetyana; Park, Hee-Won et al. (2018). Repurposing drugs to target the malaria parasite unfolding protein response. Scientific Reports 8(1) . 10.1038/s41598-018-28608-2. [PDB: 5umb] CMCF-ID Health
Chen, Yu Seby; Kozlov, Guennadi; Fakih, Rayan; Funato, Yosuke; Miki, Hiroaki et al. (2018). The cyclic nucleotide–binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+ efflux activity. Journal of Biological Chemistry 293(52) , 19998-20007. 10.1074/jbc.ra118.005672. [PDB: 6dj3] CMCF-ID Health
Crowe, Adam M.; Workman, Sean D.; Watanabe, Nobuhiko; Worrall, Liam J.; Strynadka, Natalie C. J. et al. (2018). IpdAB, a virulence factor in Mycobacterium tuberculosis , is a cholesterol ring-cleaving hydrolase. Proceedings of the National Academy of Sciences of the United States of America 115(15) , E3378-E3387. 10.1073/pnas.1717015115. [PDB: 6co6, 6co9, 6coj, 6con] CMCF-BM Health
Dementiev, Alexey; Silva, Abel; Yee, Calvin; Li, Zhe; Flavin, Michael T. et al. (2018). Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors. Blood Advances 2(5) , 549-558. 10.1182/bloodadvances.2018016337. [PDB: 6b74] CMCF-ID Health