Publication Beamlines Strategic Pillar
Tran, Norman; Frenette, Aaron; Holyoak, Todd (2025). Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases. Proceedings of the National Academy of Sciences of the United States of America 122(35) . 10.1073/pnas.2503549122. [PDB: 9ekk, 9ekm, 9ekn] CMCF-BM Agriculture
Rolfe, Nicolas; Schroeter, Kurt L.; Forrester, Taylor JB.; Kimber, Matthew S.; Seah, Stephen YK. et al. (2025). Sal is a proteobacterial bile acid aldolase that repurposes key thiolase catalytic residues for retroaldol cleavage of C5 steroid side chains. Journal of Biological Chemistry 301(8) , 110439. 10.1016/j.jbc.2025.110439. [PDB: 9myr] CMCF-BM Agriculture
Rolfe, Nicolas; Myskiw, Dustin; Patton, Matthew T.; Forrester, Taylor J. B.; Kimber, Matthew S. et al. (2025). Sad from Proteobacteria is a Structurally Distinct ALDH3 Enzyme Specialized for the Oxidation of Steroidal Aldehydes. Biochemistry 64(17) , 3735-3744. 10.1021/acs.biochem.5c00213. [PDB: 9nxl] CMCF-BM Agriculture
Hemmings, Mark; Zieliński, Michał; Golkar, Tolou; Blanchet, Jonathan; Pistofidis, Angelos et al. (2025). Enzyme-mediated aminoglycoside resistance without target mimicry. Communications Chemistry 8(1) . 10.1038/s42004-025-01666-0. [PDB: 9mgu] CMCF-ID Agriculture
Dodda, Leela S.; Campos, Sebastien; Ciccone, David; Carreiro, Samantha; Leit, Silvana et al. (2025). Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors. Journal of Medicinal Chemistry 68(17) , 18436-18462. 10.1021/acs.jmedchem.5c01231. [PDB: 9pfl] CMCF-BM Agriculture
Barghash, Marim M.; Mabanglo, Mark F.; Hoff, Samuel E.; Brozdnychenko, Dmytro; Wong, Keith S. et al. (2025). Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure . 10.1016/j.str.2025.07.013. [PDB: 9mjp] CMCF-BM Agriculture
Abdoli, Amirabbas; Yang, Zhihan; Odeh‐Ahmed, Abdullah; Bednova, Olga; Lemieux, Bruno et al. (2025). Probing the extent of importin‐α targeting of the TAF8 NLS by eliminating its cationic net‐charge. Protein Science 34(9) . 10.1002/pro.70272. [PDB: 9cl8, 9cle, 9clf, 9clg] CMCF-ID Agriculture
Hu, Zhenyu; Klupt, Kody; Zechel, David L.; Jia, Zongchao; Howe, Graeme W. et al. (2025). Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities using Sequence Similarity Networks. ChemBioChem . 10.1002/cbic.202500065. [PDB: 9eh6] CMCF-ID Environment
Ye, Qilu; Eves, Robert; Vance, Tyler D. R.; Hansen, Thomas; Sage, Adam P. et al. (2025). Aeromonas hydrophila RTX adhesin has three ligand-binding domains that give the bacterium the potential to adhere to and aggregate a wide variety of cell types. mBio 16(5) . 10.1128/mbio.03158-24. [PDB: 9cse] CMCF-ID Health
Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu et al. (2025). A neomorphic protein interface catalyzes covalent inhibition of RAS G12D aspartic acid in tumors. Science 389(6758) . 10.1126/science.ads0239. [PDB: 9ct7, 9ct9, 9cta, 9ctb] CMCF-ID Health
Walker, Morgan E.; Zhu, Wei; Peterson, Janine H.; Wang, Hao; Patteson, Jon et al. (2025). Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition. Nature Communications 16(1) . 10.1038/s41467-025-58086-w. [PDB: 9cs0, 9cs1] CMCF-ID Health
Vallée, Frédéric; Casás-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar et al. (2025). Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.5c00529. [PDB: 9o63] CMCF-ID Health
Tran, Norman; Redzic, Jasmina S.; Eisenmesser, Elan Z.; Holyoak, Todd (2025). The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain. Acta Crystallographica Section F:Structural Biology Communications 81(4) . 10.1107/s2053230x25001219. [PDB: 9ect] CMCF-BM Health
Tong, Yunsong; Baker, Kenton A.; Chapman, Alex M.; Elsen, Nathaniel L.; Fowler, Faith et al. (2025). Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. Journal of Medicinal Chemistry . 10.1021/acs.jmedchem.4c03029. [PDB: 9og8] CMCF-ID Health
Throner, Scott; Feng, Tianshu; Andersen, Jannik N.; Bandi, Madhavi; Engel, Justin L. et al. (2025). Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor. Bioorganic and Medicinal Chemistry Letters 124, 130262. 10.1016/j.bmcl.2025.130262. [PDB: 9n9y] CMCF-BM Health