Publication Beamlines Strategic Pillar
Higgins, Melanie A.; Shi, Xinjie; Soler, Jordi; Harland, Jill B.; Parkkila, Taylor et al. (2025). Structure and mechanism of haem-dependent nitrogen–nitrogen bond formation in piperazate synthase. Nature Catalysis 8(3) , 207-217. 10.1038/s41929-024-01280-8. CMCF-ID Materials
Lamberink, Jan-Willem; Kassymbek, Aishabibi; Dmitrienko, Anton; Spasyuk, Denis; Gabidullin, Bulat et al. (2026). Germylide-Catalyzed Hydrosilylation and Hydroboration: Insertion/Metathesis versus Non-hydride Mechanisms. Inorganic Chemistry . 10.1021/acs.inorgchem.6c02932. CMCF-BM Materials
Zhao, Feipeng; Zhang, Shumin; Wang, Shuo; Reid, Joel W.; Xia, Wei et al. (2025). Anion sublattice design enables superionic conductivity in crystalline oxyhalides. Science 390(6769) , 199-204. 10.1126/science.adt9678. CMCF-BM, SXRMB Materials
Dodda, Leela S.; Campos, Sebastien; Ciccone, David; Carreiro, Samantha; Leit, Silvana et al. (2025). Knowledge and Structure-Based Drug Design of 15-PGDH Inhibitors. Journal of Medicinal Chemistry 68(17) , 18436-18462. 10.1021/acs.jmedchem.5c01231. [PDB: 9pfl] CMCF-BM Materials
Merchant, R.R.; Chernyak, N.; Lopez, J.A.; Sharp, P.P.; Mandal, M. et al. (2026). N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-amino-1-[(2S)-1,1,1-trifluorobutan-2-yl]-1H-pyrazole-4-carbonyl}-6-chloro-5-fluorospiro[[3,1]benzoxazine-4,3'-piperidin]-2(1H)-one). Protein Data Bank: 10qs. CMCF-BM Materials
Carbone, Christine E.; Schönherr, Heike; Zhao, Victor Y.; Pierce, Levi; He, Jing et al. (2026). Cryptic small-molecule binding sites in the ARID1B DNA-binding domain. Proceedings of the National Academy of Sciences of the United States of America 123(33) . 10.1073/pnas.2529603123. CMCF-ID Health
Andress, Sam; McLeod, Matthew J.; Holyoak, Todd (2026). The C117D oxidation mimic reveals the monomeric structure of SARS ‐ CoV ‐2 main protease. Protein Science 35(9) . 10.1002/pro.70753. CMCF-ID Health
Fraser, Bryan J.; Young, Nicholas J.; Bender, Brian J.; Gahbauer, Stefan; Ilyassov, Olzhas et al. (2025). Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. Journal of Medicinal Chemistry 68(19) , 19893-19907. 10.1021/acs.jmedchem.4c03089. CMCF-ID Health
Fraser, Bryan J.; Wilson, Ryan P.; Ferková, Sára; Ilyassov, Olzhas; Lac, Jackie et al. (2025). Structural basis of TMPRSS11D specificity and autocleavage activation. Nature Communications 16(1) . 10.1038/s41467-025-59677-3. CMCF-ID Health
Puumala, Emily; Nandakumar, Meganathan; Yiu, Bonnie; Stogios, Peter J.; Strickland, Benjamin G. et al. (2025). Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans. Nature Communications 16(1) . 10.1038/s41467-025-57346-z. CMCF-ID Health
Nguyen, Quynh Huong; Lai, Chun Heng Royce; Norris, Michael J.; Ng, Dixon; Shah, Megha et al. (2025). A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion. PLoS Pathogens 21(5) , e1012686. 10.1371/journal.ppat.1012686. CMCF-ID Health
Ivanochko, Danton; Miura, Kazutoyo; Hailemariam, Sophia; Ravichandran, Rashmi; Song, Yiting et al. (2026). A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity. Nature Communications . 10.1038/s41467-026-68761-1. CMCF-ID Health
Govind, Manitabhai; Allas, Mikel Jason; Huang, Bo-Shun; Lowary, Todd L.; Kimber, Matthew S. et al. (2026). The retaining kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes. Journal of Biological Chemistry 302(3) , 111162. 10.1016/j.jbc.2026.111162. [PDB: 9yfx] CMCF-ID Health
Haines, Eric; Burke, Michael; Catterall, Rachel; De Jesus, Victor; Hidalgo, Daniel et al. (2026). The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers. Nature Cancer . 10.1038/s43018-025-01081-3. [PDB: 9ecu] CMCF-ID Health
Kimani, Serah W.; Noureldin, Mahmoud; Wilson, Brian; Hoffer, Laurent; Green, Stuart R. et al. (2025). OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications Biology 8(1) . 10.1038/s42003-025-08491-0. [PDB: 9yv4] CMCF-ID Health